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学科主题: 分析化学
题名: 电喷雾飞行时间质谱法研究溶液pH值5对醋氨已酸锌络合物的影响
其他题名: Effect of solution pH value on the chelation structure of zinc acexamate by electrospray ionization mass spectrometry
作者: 余翀天 ; 郭寅龙 ; 张尊建 ; 相秉仁 ; 安登魁
通讯作者: 郭寅龙
刊名: 药学学报
发表日期: 2000-01-01
卷: 35, 期:12, 页:913-915
部门归属: 中国科学院上海有机化学研究所分析化学实验室; 中国药科大学
英文摘要: To study the effect of solution Ph value on the chelation structure of zinc acexamat. A series of samples at different solution Ph values were prepared by 10% HCl or 1 mol.L-1 NH^3. H^2O. Then API/TOF MS with electrospray ion source was applied to assay the samples. The nitrogen curtain gas and nebulizer gas were adjusted to a constant flow rate of 0.6μL. Min~-1 and 2 Μl. Min~-1 respectively. Samles were infused into the electrospray interface using 500μL syringe pump at a flow rate of 5 0644L.min~-1. Mass spectra were acquired in positive ion modes by scanning over the range of m/z 100-1000. The chelation structure of zine acexa mate is stable at Ph 2.54 and it can be easy to form the ion (M+ZnY)+ (Y=CH^3CONH(CH^2)^5COO-_) and (2M+Na)+ in this condition. The drug is an effective antiulcer agent. It may decrease the acidity of stomach juice, and form a polymer to protect the ulcer.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19790
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
余翀天,郭寅龙,张尊建,等. 电喷雾飞行时间质谱法研究溶液pH值5对醋氨已酸锌络合物的影响[J]. 药学学报,2000,35(12):913-915.
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