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学科主题: 生命有机化学
题名: Enantioselective biotransformation of α ,α -disubstituted dinitriles to the corresponding 2-cyanoacetamides using Rhodococcus sp. CGMCC 0497
其他题名: 利用菌株Rhodococuus sp. CGMCC 0497将α,α-二取代丙腈类底物对映选择性地生物转化为2-氰基乙酰胺
作者: Wu ZL(吴中柳) ; Li ZY(李祖义)
通讯作者: 李祖义
刊名: Tetrahedron-Asymmetry
发表日期: 2003-01-01
卷: 14, 期:15, 页:2133-2142
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: A new application of nitrile-converting enzymes in the synthesis of optically active α ,α -disubstituted-α -cyanoacetamides from α ,α -disubstituted-malononitriles with whole cells of Rhodococcus sp. CGMCC 0497 is described. The products were obtained with enatiomeric excesses of up to >99%, and yields of up to 53%. They are very useful chiral intermediates especially for the synthesis of chiral α ,α -disubstituted amino acids but have never been synthesized directly by chemical or enzymatic methods.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19735
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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Recommended Citation:
Wu ZL,Li ZY. Enantioselective biotransformation of α ,α -disubstituted dinitriles to the corresponding 2-cyanoacetamides using Rhodococcus sp. CGMCC 0497[J]. Tetrahedron-Asymmetry,2003,14(15):2133-2142.
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