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学科主题: 生命有机化学
题名: 氰基水解酶在有机合成中的应用
其他题名: Microbial and enzymatic hydrolysis of nitriles in organic synthesis
作者: 吴中柳 ; 李祖义
通讯作者: 李祖义
刊名: 有机化学
发表日期: 2001-01-01
卷: 21, 期:1, 页:25-32
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
摘要: 腈化物是有机合成中的重要中间体,因为其中的氰基可以通过多种方法引入,又能进一步转化成其它官能团。用氰基水解酶实现氰基降解不仅反应条件温和,少污染、易处理,更重要的是能实现一般化学转化所不能实现的优良的化学、区域及立体选择性。不管是从学术角度还是工程角度来看,氰基水解酶都是一种有巨大潜力的有机合成工具。
英文摘要: Nitriles are central intermediates in organic synthesis since they can be readily prepared by a number of methods and undergo further transformations into other functional groups> Using crude enzyme preparations of whole viable microbial cells, hydrolysis of nitriles to yield amides or carboxylic acids can be performed under mild conditions with low pollution and the absence of waste disposal problems. Additionally, it can also provide high chemoslelctivity, regioselectivity and enantioselectivity which cannot be achieved by conventional organic processes. This paper is to provide an overview on the great potentiality of nitrile converting enzymes for organic synthesis not only from an academic stndpoint, but from a biotechnological point of view.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19693
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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Recommended Citation:
吴中柳,李祖义. 氰基水解酶在有机合成中的应用[J]. 有机化学,2001,21(1):25-32.
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