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学科主题: 氟化学
题名: Enantioselective Friedel-Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper-Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center
其他题名: 铜催化的吲哚与三氟乙烯基丙二酸酯虎克反应: 构建含三氟甲基的手性中心
作者: Wen LL(温乐乐) ; Shen QL(沈其龙) ; Wan XL(万小龙) ; Lv L(吕龙)
通讯作者: 吕龙
刊名: J. Org. Chem.
发表日期: 2011-01-01
卷: 76, 期:7, 页:2282-2285
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: An enantioselective alkylation of indoles with trifluoroethylidene malonates catalyzed by copper(II) bis (oxazoline) complexes has been developed. The expected adducts with a stereogenic tertiary carbon center bearing a trifluoromethyl group were obtained in excellent yields (up to 99%) and ee values (up to 96% ee). The synthetic utility of this asymmetric catalytic reaction was demonstrated by the preparation of beta-CF(3)-tryptophan and 4-CF(3)-beta-carboline in high ee.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000288692000039
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19249
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Wen LL,Shen QL,Wan XL,et al. Enantioselective Friedel-Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper-Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center[J]. J. Org. Chem.,2011,76(7):2282-2285.
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