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学科主题: 氟化学
题名: Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators
其他题名: Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators
作者: LE GIANG ; VANDEGRAAFF NICK ; RHODES DAVID I ; JONES ERIC D ; COATES JONATHAN A V ; THIENTHONG NEERANAT ; WINFIELD LISA J ; Lv L(吕龙) ; LI XINMING ; YU CHANGJIANG ; FENG XIAO ; DEADMAN JOHN J
通讯作者: DEADMAN JOHN J
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2010
卷: 20, 期:19, 页:5909-5912
收录类别: SCI
部门归属: Avexa公司; 中国科学院上海有机化学研究所
英文摘要: Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design of HIV integrase inhibitors is described. The Letter identified thiazole, oxazole, and imidazole as the most promising heterocycles. Initial SAR studies indicated that these novel series of integrase inhibitors are amenable to lead optimization. Several compounds with low nanomolar inhibitory potency are reported. (C) 2010 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000281735600067
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19229
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
LE GIANG,VANDEGRAAFF NICK,RHODES DAVID I,et al. Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators[J]. Bioorg. Med. Chem. Lett.,2010,20(19):5909-5912.
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