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学科主题: 有机化学
题名: 洛索洛芬钠的反相高效液相色谱手性拆分
其他题名: Chiral separation of loxoprofen sodium by high performance liquid chromatography
作者: 丁文静 ; 郑文华 ; 许旭 ; 王德才 ; 吕龙 ; 梁宏晞 ; 郁韵秋 ; 阮锦满
通讯作者: 许旭
刊名: 分析化学
发表日期: 2004-01-01
卷: 32, 期:7, 页:908-911
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所分析测试中心,氟化学开放实验室; 复旦大学药学院药物分析教研室; 南京宇道科技开发公司药物研究所
摘要: 使用三(对甲苯甲酸)纤维素酯手性固定相(Chiralcel OJ-R手性柱),建立了洛索洛芬钠4个手性异 构体的高效浓相色谱拆分方法。以甲醇与PH3.0的0.l mol/L醋酸,三乙胺或0.5mo/LHClO4-NaCl04按 80:20组成流动相,4个异构体中相邻峰的分离皮均达到1.7以上。确认了4个组分的结构按出峰次序依次 为:(1'R,2R)、(1'S,2R)、(1’R,2S)和(1s,2s)。对流动相中不同的PH、缓冲溶液浓度和类型以及有机改性 剂类型对分离结果的影响作了系统考察,其结果有助于更好地了解这类固定相的手性识别机理。
英文摘要: A method for chiral separation of four loxoprofen sodium optical isomers was developed by high performance liquid chromatography on the chiral stationary phase of cellulose tris (4-methylbenzoate) (Chiralcel OJ-R). The effects of pH, concentration and type of the buffer, and organic modifier's kind in the mobile phase on the resolution and retention were investigated. The good resolution was obtained with the mobile phases of methanol/0.1 mol/L acetic acid-triethylamine (or 0.5 mol/L HClO4-NaClO4) at pH 3.0 = 80/20. The resolutions with over 1.7 for all continuous peaks were shown at. the mobile phase conditions. The peak sequence was identified as (1'R,2R), (1'S,2R), (1'R,2S.), (1'S,2S). The investigated results facilitate to understand the recognized mechanism of the cellulose-based chiral stationary phase.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19167
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
丁文静,郑文华,许旭,等. 洛索洛芬钠的反相高效液相色谱手性拆分[J]. 分析化学,2004,32(7):908-911.
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