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学科主题: 生命有机化学
题名: Assembly of Digitoxin by Gold(I)-Catalyzed Glycosidation of Glycosyl o-Alkynylbenzoates
其他题名: 以糖基邻炔基苯甲酸酯为给体的金催化糖苷化反应合成digotoxin
作者: Ma YY(马玉勇) ; Li ZZ(李中正) ; Shi HF(史合芳) ; Zhang J(张健) ; Yu B(俞飚)
通讯作者: 俞飚
刊名: J. Org. Chem.
发表日期: 2011
卷: 76, 期:23, 页:9748-9756
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 海洋大学
英文摘要: Digitoxin, a clinically important cardiac trisactharicle, was assembled efficiently from digitoxigenin and 3,4-di-O-tert-butyldiphenylsilyl-D-digitoxosyl o-cyclopropylethynyl-benzoate in 9 steps and 52% overall yield via alternate glycosylation and protecting group manipulation. The present synthesis showcases the advantage of the gold(I)-catalyzed glycosylation protocol in the synthesis of glycoconjugates containing acid-labile 2-deoxysugar linkages.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000297274800022
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19159
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ma YY,Li ZZ,Shi HF,et al. Assembly of Digitoxin by Gold(I)-Catalyzed Glycosidation of Glycosyl o-Alkynylbenzoates[J]. J. Org. Chem.,2011,76(23):9748-9756.
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