中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo
其他题名: 甾体皂苷Polyphyllin D, 能体外抑制血管内皮细胞功能, 并能在体内一个斑马鱼胚胎血管生成
作者: Judy Yuet-Wa Chan ; Johnny Chi-Man Koon ; Xiaozhou Liu ; Michael Detmar ; Yu B(俞飚) ; Siu-Kai Kong ; Kwok-Pui Fung
通讯作者: Kwok-Pui Fung
刊名: J. Ethnopharmacol.
发表日期: 2011
卷: 137, 期:1, 页:64-69
收录类别: SCI
部门归属: 香港大学; 香港中文大学; ETH, 瑞士; 中科院上海有机化学研究所
英文摘要: Ethnopharmacological relevance: Angiogenesis, the process of blood vessel formation, is critical to tumour growth. The importance of angiogenesis in tumour development has lead to the development of antiangiogenic strategies to inhibit tumour growth. In this study, polyphyllin D (PD), an active component in Chinese herb, Paris polyphylla, was evaluated for its potential anti-angiogenic effects. Materials and methods: The inhibitory effects of PD on three important processes involved in angiogenesis, i.e. proliferation, migration and differentiation were examined using human microvascular endothelial cell line HMEC-1 by MTT assay, scratch assay and tube formation assay, respectively. Using zebrafish embryos as an animal model of angiogenesis, the anti-angiogenic effect of PD was further verified in vivo. Results: PD suppressed the growth of HMEC-1 cells at 0.1-0.4 mu M without toxic effects. At 0.3 mu M and 0.4 mu M, PD significantly inhibited endothelial cell migration and capillary tube formation. About 70% of the zebrafish embryos showed defects in intersegmental vessel formation upon treatment with PD at concentrations of 0.156 mu M and 0.313 mu M. Conclusion: The anti-angiogenic effects of PD have been explored in the study which implied a potential therapeutic development of PD in cancer treatment. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000295236700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19155
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2011474.pdf(825KB)----开放获取--View Download

Recommended Citation:
Judy Yuet-Wa Chan,Johnny Chi-Man Koon,Xiaozhou Liu,et al. Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo[J]. J. Ethnopharmacol.,2011,137(1):64-69.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Judy Yuet-Wa Chan]'s Articles
[Johnny Chi-Man Koon]'s Articles
[Xiaozhou Liu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Judy Yuet-Wa Chan]‘s Articles
[Johnny Chi-Man Koon]‘s Articles
[Xiaozhou Liu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2011474.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace