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学科主题: 生命有机化学
题名: Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity
其他题名: 保持Hippuristanol的抗增殖活性所必须的裸缩酮的立体结构
作者: Li W(李微) ; DANG YONGJUN ; Liu J(刘钧) ; Yu B(俞飚)
通讯作者: 刘钧 ; 俞飚
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2010
卷: 20, 期:10, 页:3112-3115
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 美国霍普金斯大学
英文摘要: Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity. (C) 2010 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000277246300020
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19121
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Li W,DANG YONGJUN,Liu J,et al. Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity[J]. Bioorg. Med. Chem. Lett.,2010,20(10):3112-3115.
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