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学科主题: 生命有机化学
题名: Polyphyllin D, A Potential Anti-Cancer Agent to Kill Hepatocarcinoma Cells with Multidrug Resistance
其他题名: Polyphyllin D, 一个杀死具有多药耐药性的肝肿瘤细胞的化合物
作者: R. K. Y. Lee ; R. C. Y. Ong ; J. Lei ; J. Y. N. Cheung ; Y. C. Li ; J. Y. W. Chan ; M. M. S. Lee ; Y. K. Suen ; K. P. Fung ; H. P. Ho ; Yu B(俞飚) ; Li M(李明) ; T. T. Kwok ; S. K. Kong
通讯作者: S. K. Kong
刊名: Curr. Chem. Biol.
发表日期: 2009-01-01
卷: 3, 页:409-419
部门归属: 香港中文大学; 上海有机所
英文摘要: To develop drugs to kill cancer cells, we chemically synthesized a number of anti-cancer agents by adding different side chains to the core backbone of saponin. With the use of bioassay-guided methods, we found one agent that possessed a high cytotoxicity to a number of cancer cell lines. Interestingly, this compound was later found to be an active component of a tradition Chinese herb Paris polyphylla known as Polyphyllin D (PD) (diosgenyl alpha-L-rhamnopyranosyl-(1->2)-(beta-L-ara-binofuranosyl-(1->4)-beta-D-glucopyranoside). In China, the rhizome of Paris polyphylla (Chong Lou) has been used as a traditional Chinese medicine to treat a number of cancers including pancreas and liver cancers for a long time. Results from our laboratory demonstrate that PD is a potent anti-cancer agent that bypasses multi-drug resistance (MDR) and induces programmed cell death in R-HepG2 cells over-expressing P-glycoprotein (P-gp). In this paper, we reviewed the mechanisms how PD overcomes the MDR and exhibits a stronger cytotoxicity in the R-HepG2 than its parent line without P-gp through mitochondrial injury.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19107
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
R. K. Y. Lee,R. C. Y. Ong,J. Lei,et al. Polyphyllin D, A Potential Anti-Cancer Agent to Kill Hepatocarcinoma Cells with Multidrug Resistance[J]. Curr. Chem. Biol.,2009,3:409-419.
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