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学科主题: 生命有机化学
题名: Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells
其他题名: Polyphyllin D诱导的线粒体分裂和直接作用于线粒体的诱导耐药HepG2细胞凋亡的行为。
作者: R. C. Y. Ong ; J. Lei ; R. K. Y. Lee ; J. Y. N. Cheung ; K. P. Fung ; C. Lin ; H. P. Ho ; Yu B(俞飚) ; M. Li ; S. K. Kong
通讯作者: S. K. Kong
刊名: Cancer Lett.
发表日期: 2008-01-01
卷: 261, 期:2, 页:158-164
收录类别: SCI
部门归属: 香港中文大学生化系; 香港中文大学电子工程系; 香港中文大学中药研究所; 中科院上海有机所生命有机重点实验室
英文摘要: We previously showed that polyphyllin D (PD) produced a stronger apoptotic effect in R-HepG2 with multi-drug resistance (MDR) than that in its parent HepG2 cells without MDR. In this study, PD was found to elicit mitochondrial fragmentation in live cells by using total internal reflection fluorescence microscopy (TIRFM). When mitochondria were isolated and treated directly with PD, a stronger swelling, deeper transmembrane depolarization, and more apoptosis-inducing factor (A IF) release were observed from the mitochondria of R-HepG2 than that of HepG2. These observations suggest that PD is a potent anti-cancer agent that bypasses MDR and elicits apoptosis via mitochondrial injury. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000254732500004
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19087
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
R. C. Y. Ong,J. Lei,R. K. Y. Lee,et al. Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells[J]. Cancer Lett.,2008,261(2):158-164.
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