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学科主题: 生命有机化学
题名: Isoflavone glycosides: Synthesis and evaluation as alpha-glucosidase inhibitors
其他题名: 异黄酮糖苷的合成及其作为α-糖苷酶抑制剂的评估.
作者: Wei G(魏国) ; Yu B(俞飚)
通讯作者: 俞飚
刊名: Eur. J. Org. Chem.
发表日期: 2008
期: 18, 页:3156-3163
收录类别: SCI
部门归属: 上海有机所
英文摘要: On the basis of the structure of 4',7,8-trihydroxyisoflavone 7-O-alpha-D-arabinofuranoside (namely A-76202, 1), a Rhodococcus metabolite showing potent inhibitory activities against the alpha-glucosidases of rat liver microsome (IC50 = 0.46 ng/mL), 26 analogs, each with minor variations at the sugar moiety and the isoflavone A and B rings, were readily synthesized. Notably, a new and efficient method was developed for the divergent synthesis of the B-ring congeners of the isoflavone glycosides by using Suzuki-Miyaura coupling as the final step. Modifications at the sugar moiety and the isoflavone A ring significantly diminish the activity, whereas variations at the B ring are largely tolerated for retaining the potent alpha-glucosidase inhibitory activity. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000257259200015
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19075
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Wei G,Yu B. Isoflavone glycosides: Synthesis and evaluation as alpha-glucosidase inhibitors[J]. Eur. J. Org. Chem.,2008(18):3156-3163.
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