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学科主题: 生命有机化学
题名: Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells
其他题名: Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells
作者: Jenny Yuen-Nei Cheung ; Rose Chik-Ying Ong ; Yick-Keung Suen ; Vincent Ooi ; Henry Nai-Ching Wong ; Thomas Chung-Wai MakKwok-Pui Fung ; Yu B(俞飚) ; Siu-Kai Kong
通讯作者: Siu-Kai Kong
刊名: Cancer Lett.
发表日期: 2005
卷: 217, 期:2, 页:203-211
收录类别: SCI
部门归属: 香港中文大学; 中科院上海有机所
英文摘要: In a search for new anticancer agents, we identified a novel compound polyphyllin D (PD) (diosgenyl alpha-L-rhamnopyranosyl(1-->2)-(alpha-L-arabinofuranosyl)-(1-->4)]-[beta -D-glucopyranoside) that induced DNA fragmentation and phosphatidyl-serine (PS) externalization in a hepatocellular carcinoma cell line HepG2 derivative with drug resistance (R-HepG2). PD is a saponin originally found in a tradition Chinese medicinal herb Paris polyphylla. It has been used to treat liver cancer in China for many years. We evaluated the cell-killing mechanisms of this compound in R-HepG2 and its parental cells. The mitochondrial apoptotic pathway was found to be involved in the PD-induced apoptosis because PD elicited depolarization of mitochondrial transmembrane potential (DeltaPsim), generation of H2O2, as well as release of cytochrome c and apoptosis-inducing factor in a dose- and time-dependent manner. In conclusion, we show for the first time that PD is a potent anticancer agent that can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000226476800009
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19017
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Jenny Yuen-Nei Cheung,Rose Chik-Ying Ong,Yick-Keung Suen,et al. Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells[J]. Cancer Lett.,2005,217(2):203-211.
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