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学科主题: 生命有机化学
题名: Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs)
其他题名: Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs)
作者: Keyong Zou ; Allen Horhota ; Yu B(俞飚) ; Jack W. Szostak ; Larry W. McLaughlin
通讯作者: Larry W. McLaughlin
刊名: Org. Lett.
发表日期: 2005
卷: 7, 期:8, 页:1485-1487
收录类别: SCI
部门归属: Howard Hughes Medical Institute and Massachusetts General Hospital; Boston College; 中科院上海有机所
英文摘要: [GRAPHICS] The alpha-L-threofuranosyl nucleoside triphosphates of T, G, and D (tTTP, tGTP, and tDTP) were synthesized from the described 2'-O-DMT-protected derivatives using the Eckstein method, while the corresponding C derivative (tCTP) was prepared from the 2'-O-acetyl derivative. The prepared alpha-L-threofuranosyl nucleoside triphosphates, despite being one carbon shorter than the native 2'-deoxyfuranosyl nucleoside triphosphates, are effective substrates for selected DNA polymerases.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000228344200013
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19011
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Keyong Zou,Allen Horhota,Yu B,et al. Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs)[J]. Org. Lett.,2005,7(8):1485-1487.
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