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学科主题: 生命有机化学
题名: Synthesis of the trisaccharide and tetrasaccharide moieties of the potent immunoadjuvant QS-21
其他题名: 免疫佐剂QS-21三糖和四糖部分的合成
作者: Zhu XM(朱向明) ; Yu B(俞飚) ; Hui YZ(惠永正) ; R. R. Schmidt
通讯作者: 朱向明
刊名: Eur. J. Org. Chem.
发表日期: 2004
期: 5, 页:965-973
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学国家重点实验室; 德国Konstanz大学
英文摘要: The title trisaccharide and tetrasaccharide moieties have been synthesized as part of our research programme to construct the complex triterpenoid saponin QS-21, a potent immunoadjuvant, which has been used in a series of clinical immunization trials. In view of the unwillingness of glucuronic acid as glycosyl acceptor, the branched glucuronic acid-containing trisaccharide 20 was synthesized from D-glucose, which was in turn glycosylated at positions 2 and 3, followed by oxidation at position 6, in a linear sequence of 15 steps and in good overall yield. The apiose-containing tetrasaccharide 36 was constructed by a linear glycosylation strategy from the non-reducing terminal sugar, D-apiose, which was prepared from D-xylose by a known procedure, also in a linear sequence of 15 steps. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000220048400003
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/18991
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Zhu XM,Yu B,Hui YZ,et al. Synthesis of the trisaccharide and tetrasaccharide moieties of the potent immunoadjuvant QS-21[J]. Eur. J. Org. Chem.,2004(5):965-973.
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