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学科主题: 生命有机化学
题名: Chemical and biological characterization of a polysaccharide biological response modifier from Aloe vera L. var. chinensis (Haw.) Berg.
其他题名: 从Aloe vera L. var. chinensis (Haw.) Berg.提取的一种生理反应调节多糖: 化学和生物学表征
作者: M. Y. K. Leung ; C. Liu ; L. F. Zhu ; Hui YZ(惠永正) ; Yu B(俞飚) ; K. P. Fung
通讯作者: K. P. Fung
刊名: Glycobiology
发表日期: 2004
卷: 14, 期:6, 页:501-510
收录类别: SCI
部门归属: 香港中文大学中药研究所; 香港中文大学生化系; 中国科学院华南植物所; 中国科学院上海有机化学研究所生命有机国家重点实验室
英文摘要: Three purified polysaccharide fractions designated as PAC-I, PAC-II, and PAC-III were prepared from Aloe vera L. var. chinensis (Haw.) Berg. by membrane fractionation and gel filtration HPLC. The polysaccharide fractions had molecular weights of 10,000 kDa, 1300 kDa, and 470 kDa, respectively. The major sugar residue in the polysaccharide fractions is mannose, which was found to be91.5% in PAC-I, 87.9% in PAC-II, and 53.7% in PAC-III. The protein contents in the polysaccharide fractions was undetectable. NMR study of PAC-I and PAC-II demonstrated the polysaccharides shared the same structure. The main skeletons of PAC-I and PAC-II are beta-(1-->4)-D linked mannose with acetylation at C-6 of manopyranosyl. The polysaccharide fractions stimulated peritoneal macrophages, splenic T and B cell proliferation, and activated these cells to secrete TNF-alpha, IL-1beta, INF-gamma, IL-2, and IL-6. The polysaccharides were nontoxic and exhibited potent indirect antitumor response in murine model. PAC-I, which had the highest mannose content and molecular weight, was found to be the most potent biological response modifier of the three fractions. Our results suggested that the potency of aloe polysaccharide fraction increases as mannose content and molecular weight of the polysaccharide fraction increase.
语种: 英语
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WOS记录号: WOS:000221405900004
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/18987
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
M. Y. K. Leung,C. Liu,L. F. Zhu,et al. Chemical and biological characterization of a polysaccharide biological response modifier from Aloe vera L. var. chinensis (Haw.) Berg.[J]. Glycobiology,2004,14(6):501-510.
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