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学科主题: 生命有机化学
题名: Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety
其他题名: 锁链二氢鼠蓣皂甙的合成
作者: Yichun Zhang ; Li YX(李英霞) ; Zhu SL(朱石磊) ; Huashi Guan ; Lin F(林峰) ; Yu B(俞飚)
通讯作者: 李英霞 ; 俞飚
刊名: Carbohydr. Res.
发表日期: 2004-01-01
卷: 339, 期:10, 页:1753-1759
收录类别: SCI
部门归属: 中国海洋大学海洋药物与食品所; 中国科学院上海有机化学研究所生命有机国家重点实验室
英文摘要: 3-O-beta-Chacotriosyl-26-O-beta-D-glucopyranosyl-(25R)-furost-5-en (1), a mimic of the antitumor active proto-dioscin, was concisely synthesized from diosgenin in a linear nine steps and in 17% overall yield. Its congeners with a alpha-L-rhamnopyranosyl, beta-lactosyl, or without a substituent at the 26-OH (13-15) were also prepared. Compound 1, as well as 13-15, did not show any inhibition against tumor cells, implying that proto-dioscin might be also inactive, but readily converted into the antitumor active dioscin. (C) 2004 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000222746900010
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/18983
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Yichun Zhang,Li YX,Zhu SL,et al. Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety[J]. Carbohydr. Res.,2004,339(10):1753-1759.
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