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学科主题: 金属有机化学 ; 分析化学
题名: Direct on-line method to monitor the dynamic structure of noncovalent titanium complexes in solution by using cold-spray ionization time-of-flight mass spectrometry
其他题名: 用冷喷雾电离TOF-MS直接即时监测溶液中非共价钛络合物动态结构的分析方法
作者: He JM(何久明) ; Zeper Abliz ; Zhang RP(张瑞萍) ; Liang YX(梁毓学) ; Ding KL(丁奎岭)
通讯作者: Zeper Abliz
刊名: Anal. Chem.
发表日期: 2006
卷: 78, 期:13, 页:4737-4740
收录类别: SCI
部门归属: 中国医学科学院及中国协和医科大学药物研究所; 中科院上海有机化学研究所金属有机化学国家重点实验室
英文摘要: In this paper, we report the feasibility of using the online cold-spray ionization time-of-flight mass spectrometry (CSI-TOFMS) method to monitor directly the labile noncovalent organometallic complexes formed in the substitution reaction between a chiral titanium asymmetric catalyst and organic acid in the toluene solvent. The comparison between the conventional ESI and CSITOFMS spectra of [(S) 1](2)Ti-2[(S)2](2) in THF indicated that the CSI-TOFMS is an effective method to characterize the structures of labile organometallic complexes in solution. A new strategy was designed so that [( S)1](2)Ti-2[(S)2](2) and organic acid solution were delivered independently to the CSI ion source by two infusion syringe pumps, and they mixed at a triple valve, and then the substitution reaction occurred in the sprayer. The mix and reaction time was similar to 5 s and can be adjusted by the length of the PEEK tube and the flow rate. The reaction products were ionized and detected directly by the CSI-TOFMS. Organic acids, such as formic, acetic, phenylpropionic, anisic, and paramethoxylphenylactic acids, were investigated. From the on line CSI-TOFMS spectra, it is observed clearly that one or two ( S) 2 group( s) can be substituted by the added acid to form new species. The results obtained here demonstrated that the designed strategy with on line CSI-TOFMS is effective and reliable to elucidate the dynamic structure of noncovalent titanium complexes in reaction solution.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000238665200069
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17821
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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Recommended Citation:
He JM,Zeper Abliz,Zhang RP,et al. Direct on-line method to monitor the dynamic structure of noncovalent titanium complexes in solution by using cold-spray ionization time-of-flight mass spectrometry[J]. Anal. Chem.,2006,78(13):4737-4740.
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