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学科主题: 金属有机化学
题名: Combinatorial approach to chiral catalyst engineering and screening: Rational design and serendipity
其他题名: 组合不对称催化:合理设计与偶然机遇
作者: Ding KL(丁奎岭) ; Du HF(杜海峰) ; Yuan Y(袁宇) ; Long J(龙江)
通讯作者: 丁奎岭
刊名: Chem.-Eur. J.
发表日期: 2004
卷: 10, 期:12, 页:2872-2884
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: An efficient asymmetric catalyst relies on the successful combination of a large number of interrelated variables, including rational design, intuition, persistence, and good fortune-not all of which are necessarily well-understood; this renders such practice largely empirical. As a result, the possibility of using combinatorial chemistry methods in asymmetric catalysis research has been widely recognized to be highly desirable. In this account, we attempt to show the principle and application of combinatorial approach in the discovery of chiral catalysts for enantioselective reactions. The concept focuses on the strategy for the creation of a modular chiral catalyst library by two-component ligand modification of metal ions on the basis of molecular recognition and assembly. The self-assembled chiral catalyst with two different ligands indeed exhibited synergistic effects in terms of both enantioselectivity and activity in comparison with its corresponding homocombinations in many reactions. The examples described in this paper demonstrated the powerfulness of combinatorial approach for the discovery of novel chiral catalyst systems, particularly for the development of highly efficient, enantioselective, and practical catalysts for enantioselective reactions. We hope this concept will stimulate further work on the discovery of more highly efficient and enantioselective catalysts, as well as unexpected classes of catalysts or catalytic enantioselective reactions in the future with the help of a combinatorial chemistry approach.
语种: 英语
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WOS记录号: WOS:000222312800001
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17771
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ding KL,Du HF,Yuan Y,et al. Combinatorial approach to chiral catalyst engineering and screening: Rational design and serendipity[J]. Chem.-Eur. J.,2004,10(12):2872-2884.
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