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学科主题: 氟化学 ; 生命有机化学
题名: Synthesis of monofluorinated isofagomine analogues and evaluation as glycosidase inhibitors
其他题名: Isofagomine的单氟类似物的合成和作为糖苷酶抑制剂活性测试
作者: Yang Y(杨义) ; Zheng F(郑峰) ; Mikael Bols ; Lavinia G. Marinescu ; Qing FL(卿凤翎)
通讯作者: 卿凤翎
刊名: J. Fluor. Chem.
发表日期: 2011
卷: 132, 期:10, 页:838-845
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 哥本哈根大学
英文摘要: The straightforward synthesis of monofluorinated isofagomine analogues 1-3 was described. The synthetic strategy featured that the chiral carbon center bearing fluorine atom was constructed stereoselectively via silicon-induced Reformatskii-Claisen rearrangement of allyl bromofluoroacetate. These compounds were tested for inhibition of five glycosidases. The 3S,4R,5R isomer 3 has been found to be a potent inhibitor against beta-glucosidase from almonds with K(i) value of 11.9 mu M. (C) 2011 Elsevier B.V. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000294876900030
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17703
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Yang Y,Zheng F,Mikael Bols,et al. Synthesis of monofluorinated isofagomine analogues and evaluation as glycosidase inhibitors[J]. J. Fluor. Chem.,2011,132(10):838-845.
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