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Recent Advances in the Synthesis of Fluorinated Amino Acids
其他题名含氟氨基酸的合成进展
Qiu XL(邱小龙); Qing FL(卿凤翎)
2011
发表期刊Eur. J. Org. Chem.
ISSN1434-193X
期号18页码:3261-3278
摘要Introduction of fluorine atoms or fluorine-containing groups into amino acids has attracted much attention from bioorganic and medicinal chemists because the resulting fluorinated amino acids have found wide application as potential enzyme inhibitors and antitumor (antibacterial) agents. Additionally, it is well known that replacement of naturally occurring amino acid(s) in some peptide chains with their fluorinated counterparts can significantly increase specific protein-ligand or protein-protein interactions, leading to in-creases in the proteolytic and thermal stabilities of peptide compounds and, as a result, promote their therapeutic properties. This microreview summarizes important advances in the synthesis of fluorinated amino acids since 2005. The contents are simply divided into three groups on the basis of amino acid types: fluorinated alpha-amino acids (F-alpha AAs), fluorinated beta-amino acids (F-beta AAs), and fluorinated cyclic amino acids (F-CAAs).
学科领域氟化学 ; 生命有机化学
部门归属中科院上海有机化学研究所; 海门慧聚药业有限公司; 东华大学
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收录类别SCI
语种英语
WOS记录号WOS:000291583700001
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被引频次:92[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/17697
专题中科院有机氟化学重点实验室
通讯作者Qing FL(卿凤翎)
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GB/T 7714
Qiu XL,Qing FL. Recent Advances in the Synthesis of Fluorinated Amino Acids[J]. Eur. J. Org. Chem.,2011(18):3261-3278.
APA 邱小龙,&卿凤翎.(2011).Recent Advances in the Synthesis of Fluorinated Amino Acids.Eur. J. Org. Chem.(18),3261-3278.
MLA 邱小龙,et al."Recent Advances in the Synthesis of Fluorinated Amino Acids".Eur. J. Org. Chem. .18(2011):3261-3278.
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