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学科主题: 氟化学 ; 生命有机化学
题名: Recent Advances in the Synthesis of Fluorinated Amino Acids
其他题名: 含氟氨基酸的合成进展
作者: Qiu XL(邱小龙) ; Qing FL(卿凤翎)
通讯作者: 卿凤翎
刊名: Eur. J. Org. Chem.
发表日期: 2011
期: 18, 页:3261-3278
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 海门慧聚药业有限公司; 东华大学
英文摘要: Introduction of fluorine atoms or fluorine-containing groups into amino acids has attracted much attention from bioorganic and medicinal chemists because the resulting fluorinated amino acids have found wide application as potential enzyme inhibitors and antitumor (antibacterial) agents. Additionally, it is well known that replacement of naturally occurring amino acid(s) in some peptide chains with their fluorinated counterparts can significantly increase specific protein-ligand or protein-protein interactions, leading to in-creases in the proteolytic and thermal stabilities of peptide compounds and, as a result, promote their therapeutic properties. This microreview summarizes important advances in the synthesis of fluorinated amino acids since 2005. The contents are simply divided into three groups on the basis of amino acid types: fluorinated alpha-amino acids (F-alpha AAs), fluorinated beta-amino acids (F-beta AAs), and fluorinated cyclic amino acids (F-CAAs).
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000291583700001
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17697
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Qiu XL,Qing FL. Recent Advances in the Synthesis of Fluorinated Amino Acids[J]. Eur. J. Org. Chem.,2011(18):3261-3278.
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