中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 中科院有机氟化学重点实验室  > 期刊论文
学科主题: 氟化学
题名: Difluoromethylenated Polyhydroxylated Pyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation
其他题名: 含二氟亚甲基多羟基吡咯: 合成、晶体结构和生物活性
作者: Wang RW(王若文) ; Xu J(徐军) ; Oscar Lopez ; Mikael Bols ; Qing FL(卿凤翎)
通讯作者: 卿凤翎
刊名: Future Med. Chem.
发表日期: 2009
卷: 1, 期:5, 页:991-997
收录类别: SCI
部门归属: 上海有机所; Univ Copenhagen
英文摘要: In our ongoing program aimed atthe design, synthesis and biological evaluation of novel gem-difluoromethylenated glycosidase inhibitors, the gem-difluoromethylenated polyhydroxylated pyrrolidines as analogues of 2.5-dideoxy-2.5-imino-D-mannitol (DMDP) were designed and prepared. The crystal structure of gem-difluoromethylenated polyhydroxylated pyrrolidine 17 contains an N-H...F intermolecular hydrogen bond. The biological assessment of gem-difluoromethylenated polyhydroxylated pymlidines showed that the modification by the gem-difluoromethylene group decreased the inhibitory activities of DMDP.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000276093600020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17663
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2009634.pdf(341KB)----开放获取--View Download

Recommended Citation:
Wang RW,Xu J,Oscar Lopez,et al. Difluoromethylenated Polyhydroxylated Pyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation[J]. Future Med. Chem.,2009,1(5):991-997.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[王若文]'s Articles
[徐军]'s Articles
[Oscar Lopez]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[王若文]‘s Articles
[徐军]‘s Articles
[Oscar Lopez]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2009634.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace