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学科主题: 氟化学 ; 生命有机化学
题名: Nucleophilic addition of 3,3,3-trifluoropropynyllithium to D-glyceraldimine: Concise synthesis of both enantiomers of 5,5,5-trifluoronorvaline
其他题名: Nucleophilic addition of 3,3,3-trifluoropropynyllithium to D-glyceraldimine: Concise synthesis of both enantiomers of 5,5,5-trifluoronorvaline
作者: Chen Q(陈琦) ; Qiu XL(邱小龙) ; Qing FL(卿凤翎)
通讯作者: 卿凤翎
刊名: J. Fluor. Chem.
发表日期: 2007
卷: 128, 期:10, 页:1182-1186
收录类别: SCI
部门归属: 上海有机所; 东华大学
英文摘要: 3,3,3-Trifluoropropynyllithium, in situ generated by treatment of 2-bromo-3,3,3-trifluoro-1-propene 1 with 2.0 equiv. of LDA at -78 degrees C, was trapped with D-glyceraldimine 2 to give trifluoromethylated propargylic amine 4 in 55% yield. Starting from the key intermediate 4, Boc-protected (R)-5,5,5-trifluoronorvaline and (S)-5,5,5-trifluoronorvaline were concisely synthesized over three steps in 62% and 63% yield, respectively. (C) 2007 Published by Elsevier B.V.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000250619900017
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17621
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Chen Q,Qiu XL,Qing FL. Nucleophilic addition of 3,3,3-trifluoropropynyllithium to D-glyceraldimine: Concise synthesis of both enantiomers of 5,5,5-trifluoronorvaline[J]. J. Fluor. Chem.,2007,128(10):1182-1186.
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