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学科主题: 氟化学 ; 生命有机化学
题名: Synthesis of a series of novel 2 ',3 '-dideoxy-6 ',6 '-difluoro-3 '-thionucleosides
其他题名: Synthesis of a series of novel 2',3'-dideoxy-6',6'-difluoro-3'-thionucleosides
作者: Le XY(乐旭义) ; Wu YY(吴芸芸) ; Qing FL(卿凤翎)
通讯作者: 卿凤翎
刊名: Tetrahedron
发表日期: 2007
卷: 63, 期:7, 页:1560-1567
收录类别: SCI
部门归属: 上海有机所; 东华大学
英文摘要: A series of novel 2,3'-dideoxy-6',6'-difluoro-3'-thionucleosides 1a-d, analogues of 3TC that has high biological activities against HlV and HBV, have been synthesized from the gem-difluorohomoallyl amine 7 in a straightforward fashion. Our synthesis featured the construction of thiofuranose skeleton through ring closure of key intermediates and installation of pyrimidine ring with amino group in compounds 13a,b. (c) 2006 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000244121200005
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17609
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Le XY,Wu YY,Qing FL. Synthesis of a series of novel 2 ',3 '-dideoxy-6 ',6 '-difluoro-3 '-thionucleosides[J]. Tetrahedron,2007,63(7):1560-1567.
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