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学科主题: 氟化学 ; 生命有机化学
题名: Synthesis of new 2 ',3 '-dideoxy-6 ',6 '-difluoro-3 '-thionucleoside from gem-difluorohomoallyl alcohol
其他题名: 以二氟亚甲基高烯丙醇出发合成新型的2',3'-二去氧-6',6'-二氟硫核苷
作者: Wu YY(吴芸芸) ; Zhang XG(张兴刚) ; Meng WD(孟卫东) ; Qing FL(卿凤翎)
通讯作者: 卿凤翎
刊名: Org. Lett.
发表日期: 2004
卷: 6, 期:22, 页:3941-3944
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所元素有机化学实验室; 东华大学
英文摘要: 2',3'-Dideoxy-6',6'-difluoro-3'-thionucleoside 1b, an analogue of 3Tc that has high biological activities against HIV and HBV, has been synthesized from gem-difluorohomoallyl alcohol 3 in an efficient way. The key intermediate 4-amino-3,3-difluorotetrahydrothiophen-2-ylmethyl benzoate 15 was prepared from 2,2-difluoro-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol 3 in 11 steps. The construction of pyrimidine ring with the amino group of compound 15 gave the target compound 1.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000224691900016
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17525
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Wu YY,Zhang XG,Meng WD,et al. Synthesis of new 2 ',3 '-dideoxy-6 ',6 '-difluoro-3 '-thionucleoside from gem-difluorohomoallyl alcohol[J]. Org. Lett.,2004,6(22):3941-3944.
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