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学科主题: 氟化学
题名: Synthesis of novel L-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidines fromα-trifluoromethyl-α,β-unsaturated ester
其他题名: 从α-三氟甲基-α,β-不饱和酯酸合成 L-2',3'二双去氧-2'-三氟甲基的硫代核苷
作者: Zhang XG(张新刚) ; Qing FL(卿凤翎)
通讯作者: 卿凤翎
刊名: J. Org. Chem.
发表日期: 2002-01-01
卷: 67, 期:3, 页:1016-1019
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所元素有机化学实验室
英文摘要: A short and efficient synthesis of L-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidines is described. (2R,4S/2S,4S)-5-(tert-Butyldimethylsiloxy)-2-trifluoromethylpentan-4-olide(3a and 3b) are prepared from α-trifluoromethyl-α,β-unsaturated ester (1) in three steps and converted to compounds 6a and 6b. The corresponding 1-O-acetyl derivatives 8a and 8b were obtained via the usual pummerer rearrangement from 6a and 6b in two steps, which were in turn used to synthesize L-4'-thiocytidines 10a and 10b.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17489
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Zhang XG,Qing FL. Synthesis of novel L-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidines fromα-trifluoromethyl-α,β-unsaturated ester[J]. J. Org. Chem.,2002,67(3):1016-1019.
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