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学科主题: 氟化学
题名: Synthesis of 2',3'-Dideoxy-2'-trifluoromethylnucleosides from α-Trifluoromethyl-α,β-unsaturated ester
其他题名: 从α三氟甲基α,β-不饱和酯出发合成2',3'-双脱氧-2'-三氟甲基化的核苷
作者: Zhang XG(张新刚) ; Qing FL(卿凤翎) ; Yu YH(余亦华)
通讯作者: 卿凤翎
刊名: J. Org. Chem.
发表日期: 2000-01-01
卷: 65, 期:21, 页:7075-7082
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所氟有机化学开放实验室
英文摘要: The treatment ofα-bromo-α,β-unsaturated esters 2 with FSO^2CF^2CO^2Me and CuI in DMF/HMPA constitutes a new synthetic scheme for the preparation of α-trifluoromethyl-α,β-unsaturated esters 3.The trifluoromethylation of (Z)(E)-ethyl 3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-bromo-2-propenoate (2e), which is derived from 1-(R)-glyceraldehyde acetonide, yields the key intermediate α-trifluoromethyl-α,β-unsaturated esters 3e. This is transformed into anomeric acetates 8a and 8b and is used for the synthesis of a number of 2',3'-dideoxy-2'-trifluoromethylnucleosides.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17467
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Zhang XG,Qing FL,Yu YH. Synthesis of 2',3'-Dideoxy-2'-trifluoromethylnucleosides from α-Trifluoromethyl-α,β-unsaturated ester[J]. J. Org. Chem.,2000,65(21):7075-7082.
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