中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 上海有机化学研究所  > 期刊论文
学科主题: 生命有机化学
题名: Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
其他题名: 原癌基因RET启动子序列形成的全平行的G四联体的溶液结构
作者: Tong XT(童孝田) ; Lan WX(蓝文贤) ; Zhang X(张许) ; Wu HM(吴厚铭) ; Liu ML(刘买利) ; Cao CY(曹春阳)
通讯作者: 童孝田 ; 曹春阳
刊名: Nucleic Acids Res.
发表日期: 2011
卷: 39, 期:15, 页:6753-6763
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 中科院武汉物理数学研究所
英文摘要: RET protein functions as a receptor-type tyrosine kinase and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the promoter plays an important role in the transcriptional regulation of RET. Here, we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K(+) solution. The overall G-quadruplex is composed of three stacked G-tetrad and four syn guanines, which shows distinct features for all parallel-stranded folding topology. The core structure contains one G-tetrad with all syn guanines and two other with all anti-guanines. There are three double-chain reversal loops: the first and the third loops are made of 3 nt G-C-G segments, while the second one contains only 1 nt C10. These loops interact with the core G-tetrads in a specific way that defines and stabilizes the overall G-quadruplex structure and their conformations are in accord with the experimental mutations. The distinct RET promoter G-quadruplex structure suggests that it can be specifically involved in gene regulation and can be an attractive target for pathway-specific drug design.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000294555800044
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17403
Appears in Collections:上海有机化学研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2011364.pdf(7446KB)----开放获取--View Download

Recommended Citation:
Tong XT,Lan WX,Zhang X,et al. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence[J]. Nucleic Acids Res.,2011,39(15):6753-6763.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[童孝田]'s Articles
[蓝文贤]'s Articles
[张许]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[童孝田]‘s Articles
[蓝文贤]‘s Articles
[张许]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2011364.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace