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学科主题: 生命有机化学
题名: Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch
其他题名: Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch
作者: Zhu J(朱静) ; Tong XT(童孝田) ; Cao CY(曹春阳) ; Wu G(吴宫) ; Zhang NX(张乃霞) ; Wu HM(吴厚铭)
通讯作者: 吴厚铭
刊名: Biochem. Biophys. Res. Commun.
发表日期: 2010
卷: 391, 期:1, 页:627-633
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: The solution structure of BmK alpha Tx11 presented by this paper is distinctive from any other structures of wide-type scorpion alpha-toxins reported so far, for its trans-9,10 peptide bond conformation is accompanied by 'protruding' topology of the 'NC-domain'. The orientation of the C-tail of BmK alpha Tx11 is obviously different from that of classical alpha-toxins (e g., AaH2, BmK-M8), despite the fact that they share common trans conformation of peptide bond between residues 9 and 10 Accordingly, there must be other structural factors dominating the orientation of the C-tail except the conformation of peptide bond 9-10. Our study reveals that residues at position 58 play an important role in it, and different type of residues at this position (e g.. Lys. Arg, Met, Ile) result in different spatial relationship between the C-terminus and the 'five-residue-turn' and then different topology of the 'NC-domain', therefore residues at position 58 are believed to function as structure and bioactivity switch for specificity of scorpion alpha-toxins The mechanism for stabilizing the geometry of the 'NC-domain' in wide-type scorpion alpha-toxins is also discussed (C) 2009 Elsevier Inc. All rights reserved
语种: 英语
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WOS记录号: WOS:000273624500110
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17399
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Zhu J,Tong XT,Cao CY,et al. Solution structure of BmK alpha Tx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch[J]. Biochem. Biophys. Res. Commun.,2010,391(1):627-633.
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