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学科主题: 天然产物有机化学
题名: Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex
其他题名: Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex
作者: Zhou YJ(周永军) ; Li JL(李嘉良) ; Zhu J(朱静) ; Chen S(陈实) ; Zhou XF(周秀芬) ; Wu HM(吴厚铭) ; Deng ZX(邓子新)
通讯作者: 吴厚铭 ; 邓子新
刊名: Chem. Biol.
发表日期: 2008
卷: 15, 期:6, 页:629-638
收录类别: SCI
部门归属: 上海交通大学; 上海有机化学研究所
英文摘要: FR-008/candicidin is a heptaene macrolide with established antifungal activity, produced by Streptomyces sp. FR-008 as a complex mixture of compounds. Here, six components (FR-008-I to -VI) of the FR-008/candicidin complex were determined; III, V, and A were confirmed as natural products, principally differing from each other at C-3 and C-9, while the other three were believed to originate from the respective conversions of the natural ones in vitro. Inactivation of KR21 and DH18, respectively, abolished production of V carrying a C-3 hydroxyl, and VI carrying a C-9 methylene. Combined inactivation created a mutant producing only III, with a C-3 ketone and a C-9 hydroxyl, and having antifungal activity superior to V and comparable to VI. Incomplete activities of KR21 and DH18 were, therefore, unambiguously identified as being involved in structural variations of FR-008 complex.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000257198600014
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17395
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Zhou YJ,Li JL,Zhu J,et al. Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex[J]. Chem. Biol.,2008,15(6):629-638.
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