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学科主题: 生命有机化学
题名: DNA: 23-Oxa-OSW-1 生物靶标 ?
其他题名: DNA: A biological target of 23-Oxa-OSW-1 ?
作者: Guan W(关 文) ; Liu H(刘辉) ; Shen J(申杰) ; Tang PP(汤平平) ; Wu HM(吴厚铭) ; Zhang GA(张国安) ; Cao CY(曹春阳)
通讯作者: 曹春阳
刊名: 化学学报
发表日期: 2008-01-01
卷: 66, 期:14, 页:1745-1748
收录类别: SCI
部门归属: 杭州农业大学; 上海有机所
英文摘要: The anticancer drug, steroidal saponin OSW-1 was isolated from the bulbs of Ornithogalum saundersiae. Its analogue 23-Oxa-OSW-1 was found to strongly suppress the growth of the malignant tumor cells with an IC50 0.052 similar to 0.4 mu mol center dot L-1, as potent as OSW-1. However its target in vivo is still unknown. In this paper, by using ID and 2D H-1 NMR techniques, it was found that 23-Oxa-OSW-1 could interact with DNA. Further analysis of the NMR data indicated that its xylose part might be involved in its interaction with DNA. In addition, to our knowledge, the detailed assignment of 23-Oxa-OSW-1 H-1 chemical shifts done here has never been reported so far.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17393
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
关 文,Liu H,Shen J,et al. DNA: 23-Oxa-OSW-1 生物靶标 ?[J]. 化学学报,2008,66(14):1745-1748.
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