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学科主题: 生命有机化学
题名: Solution structure of BmKK4, the first member of subfamily alpha-KTx 17 of scorpion toxins
其他题名: 蝎毒α-KTx 17亚家族的第一个成员BmKK4的溶液结构
作者: Zhang NX(张乃霞) ; Chen X(陈翔) ; Li MH(李明华) ; Cao CY(曹春阳) ; Wang YF(王跃丰) ; Wu G(吴宫) ; Hu GY(胡国渊) ; Wu HM(吴厚铭)
通讯作者: 吴厚铭
刊名: Biochemistry
发表日期: 2004
卷: 43, 期:39, 页:12469-12476
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室; 中国科学院上海药物所
英文摘要: BmKK4 is a 30 amino acid peptide purified from the venom of the Chinese scorpion Buthus martensi Karsch. It has been classified as the first member of scorpion toxin subfamily alpha-KTx 17. The 3D structure of BmKK4 in solution has been determined by 2D NMR spectroscopy. This toxin adopts a common alpha/beta-motif, but shows a distinctive local conformation. The most novel feature is that the regular arrangements of the side chains of the residues involved in the beta-sheet of BmKK4 are distorted by a classic beta-bulge structure, which involves two residues (Asp18 and Arg19) in the first strand opposite a single residue (Tyr26) in the second strand. The bulge produces two main changes in the structure of the antiparallel beta-sheet: (1) It disrupts the normal alteration of the side chain direction; the side chain of Asp18 turns over to form a salt bridge with that of Arg19. (2) It accentuates the twist of the sheet, and alters the direction of the antiparallel beta-sheet. The unusual structural feature of the toxin is attributed to the shorter peptide segment (Leu15 - Arg19) between the third and fourth Cys residues and two unique residues (Asp18 and Arg19) at the position preceding the fourth Cys. In addition, the lower affinity of the peptide for the Kv channel is correlated to the structural features: residue Arg 19 instead of a Lys residue at the critical position for binding and the salt bridge formed between residues Arg19 and Asp18.
语种: 英语
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WOS记录号: WOS:000224231500008
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17337
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Zhang NX,Chen X,Li MH,et al. Solution structure of BmKK4, the first member of subfamily alpha-KTx 17 of scorpion toxins[J]. Biochemistry,2004,43(39):12469-12476.
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