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学科主题: 生命有机化学
题名: BmTx3B, a novel scorpion toxin from buthus martensi karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons
其他题名: BmTx3B, 马氏钳蝎毒液中的一个新颖毒素, 抑制海马神经元的加电流
作者: Li MH(李明华) ; Wang YF(王跃丰) ; Chen XQ(陈雪琴) ; Zhang NX(张乃霞) ; Wu HM(吴厚铭) ; Hu GY(胡国渊)
通讯作者: 胡国渊
刊名: Acta Pharmacol. Sin.
发表日期: 2003
卷: 24, 期:10, 页:1016-1020
收录类别: SCI
部门归属: 中国科学院上海药物所; 中国科学院上海有机化学研究所生命有机国家开放实验室
英文摘要: To examine the effect of BmTx3B, a novel shon-chain peptide isolated from the venom of Asian scorpion Buthus Hlartensi Karsch, on voltage-gated potassium channels. METHODS: Two types of voltage-dependent potassium currents were recorded from dissociated hippocampal neurons of neonatal rat in whole-cell voltage-clamp mode, and separated based upon their kinetic propeHies. RESULTS: BmTx3B (1O-IOO pmol/L) selectively inhibited the delayed rectifier potassium current (IK), without affecting the fast transient potassium cunent (IA). The inhibition of the peptide on IK was reversible, concentration-dependent and voltage-independent. BmTx3B did not affect the steady-state activation and inactivation kinetics of the current. CONCLUSION: The shoH-chain scorpion peptide BmTx3B selectively blocked the delayed rectifier potassium channel.
语种: 英语
WOS记录号: WOS:000185749400011
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17325
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Li MH,Wang YF,Chen XQ,et al. BmTx3B, a novel scorpion toxin from buthus martensi karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons[J]. Acta Pharmacol. Sin.,2003,24(10):1016-1020.
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