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学科主题: 天然产物有机化学
题名: Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert
其他题名: Intercedensides A-C, 二色卓片海参中的三个新三萜皂甙
作者: Zou ZR(邹峥嵘) ; Yi YH(易杨华) ; Wu HM(吴厚铭) ; Wu JH(吴久红) ; Chih-Chaung Liaw ; Kuo-Hsiumg Lee
通讯作者: 易杨华
刊名: J. Nat. Prod.
发表日期: 2003
卷: 66, 期:8, 页:1055-1060
收录类别: SCI
部门归属: 第二军医大学; 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: Three new triterpene glycosides. Intercedensides A (1), B (2). And C (3), were isolated from the sea cucumber Mensamria infeTcedens Lampert. Which is found in the South China Sea. And their structures have been elucidated by spectroscopic analysis (NMR and ESIMS) and chemical transformations. Intercedensides A (1) and C (3) have a conjugated double bond (22E.24-diene) in the side chain of the aglycon. Intercedenside B (2) has two β-o-xylose and two sulfate groups in the carbohydrate chain. II tfir-ee glycosides showed significant cytotoxicity against 1O human tumor cell lines with Edso in the range 0.6-4.0 pg/mL. Intercedenside A (1) exhibited significant in vivo antineoplastic activity against mouse Lewis lung cancer and mouse SI80 sarcoma. On the basis of these initially promising results, intercedensides A-C merit further study as potential anticancer agents.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000184942300004
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17317
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Zou ZR,Yi YH,Wu HM,et al. Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert[J]. J. Nat. Prod.,2003,66(8):1055-1060.
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