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学科主题: 生命有机化学
题名: BmKK4, a novel toxin from the venom of Asian scorpion Buthus martensi Karsch, inhibits potassium current in rat hippocampal neurons in vitro
其他题名: BmKK4, 从马氏钳蝎毒液中得到的新颖毒素体外抑制海马神经元的钾离子电流
作者: Li MH(李明华) ; Zhang NX(张乃霞) ; Chen XQ(陈雪琴) ; Wu G(吴宫) ; Wu HM(吴厚铭) ; Hu GY(胡国渊)
通讯作者: 胡国渊
刊名: Toxicon
发表日期: 2003-01-01
卷: 42, 期:2, 页:199-205
收录类别: SCI
部门归属: 上海药物所; 中国科学院上海有机化学研究所生命有机国家开放实验室
英文摘要: A novel sbon-chain peptide BmKK4 was isolated from the venom of Asian scorpion Buthus martensi Karsch. It is composed of 30 amino acids including six cysteine residues. And shares less than 25% sequence identity with the known α-KTx toxins. The action of BmKK4 on voltage-dependent potassium cuments was examined in acutely dissociated hippocampal neurons of tat. BmKIC4 (1O- 1OO Μm) inhibited both the delayed rectifier and fast transient potassium cunent in concentration-dependent malnlers. The inhibition was reversible and voltage-independent. BmKK4 caused a depolarizing shift (about 1O mV) of the Steady-state activation curve of the cuments, without changing their steady-state inactivation behavior. The unique amino acid sequence and electrophysiological e8ects suggest that BmKK4 represent a new subfamily of potassium channel toxins.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17313
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Li MH,Zhang NX,Chen XQ,et al. BmKK4, a novel toxin from the venom of Asian scorpion Buthus martensi Karsch, inhibits potassium current in rat hippocampal neurons in vitro[J]. Toxicon,2003,42(2):199-205.
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