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学科主题: 生命有机化学
题名: Solution structure of BmP01 from the venom of scorpion buthus martensii karsch
其他题名: 马氏钳蝎毒液的神经肽BmP01 的溶液结构
作者: Wu G(吴宫) ; Li YM(李医明) ; Wei DS(魏东升) ; He FH(何发虎) ; Jiang SK(江绍开) ; Hu GY(胡国圆) ; Wu HM(吴厚铭)
通讯作者: 吴宫 ; 李医明 ; 何发虎 ; 江绍开 ; 吴厚铭
刊名: Biochem. Biophys. Res. Commun.
发表日期: 2000
卷: 276, 期:3, 页:1148-1154
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室; 中科院上海药物所
英文摘要: From the venom of scorpion Buthus martensii Karsch, a short peptide (BmPO1, 29 amino acid resi-dues) was isolated and characterized as previously reported (Lebren, ft. IL, a at. (1997) Eur. J. Biochem. 245,457-464). It was shown to reduce 33% outward K~+ channel (hippocampal neurons) currents at 10 μM. The solution structure of BmPO1 was determined by 2D 1~H NMR spectroscopy. The NOEs, coupling constants, and H-D exchange obtained from NMR spectroscopy were used in structural calculations. The conformation of BmPO1 is composed of a short a-helix (Cys 3-Thr 12) and a two-stranded antiparallel β-sheet (Ala 15-Asp 20 and Lys 23-Pro 28). There are three disuffide bridges (Cys 3-Cys 19, Cys 6-Cys 24 and Cys 10-Cys 26) connecting theα-helix and β-sheet. Asp 20 to Lys 23 form a type II turn linking the two strands. Structural and electrostatic potential comparison be-tween BmPO1 and its analogues are also presented.
语种: 英语
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WOS记录号: WOS:000089794300052
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/17261
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Wu G,Li YM,Wei DS,et al. Solution structure of BmP01 from the venom of scorpion buthus martensii karsch[J]. Biochem. Biophys. Res. Commun.,2000,276(3):1148-1154.
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