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学科主题: 天然产物有机化学
题名: Environmentally benign synthesis of natural glycosides using apple seed meal as green and robust biocatalyst
其他题名: Environmentally benign synthesis of natural glycosides using apple seed meal as green and robust biocatalyst
作者: YU HUILEI ; Xu JH(许建和) ; Lu WY(卢文芽) ; Lin GQ(林国强)
通讯作者: 许建和 ; 林国强
刊名: J. Biotechnol.
发表日期: 2008
卷: 133, 期:4, 页:469-477
收录类别: SCI
部门归属: 华东理工大学; 上海有机所
英文摘要: Salidroside is a natural glycoside with pharmacological activities of resisting anoxia, microwave radiation and fatigue, improving oxygen lack, and postponing ageing. In this work, salidroside and other natural glucosides such as cinnamyl O-beta-D-glucopyranoside and 4-methoxybenzyl O-beta-D-glucopyranoside were efficiently synthesized via an environmentally benign and energy economic process. In the synthetic process, apple seed, easily available from discards of fruit processing factories, was employed as a natural and green catalyst. Moreover, all of the catalyst, solvent and excessive substrate was reused or recycled. The biocatalytic reaction was carried out in a clean and less toxic medium of aqueous tert-butanol and the glucoside produced was selectively removed from reaction mixture by alumina column adsorption, making excessive substrate (aglycon) recyclable for a repeated use in the next batch of reaction. For improvement of the biocatalyst stability, apple seed meal was further cross-linked by glutaraldehyde, yielding a net-like porous structure within which the dissociating proteins were immobilized, resulting in improved permeability of the biocatalyst. After the simple cross-linking treatment, the half-life of apple seed catalyst was significantly improved from 29 days to 51 days. The productivity of the bioreactor in the case of salidroside can reach ca. 1.9 g l(-1) d(-1), affording the product in up to 99.3% purity after refinement. (C) 2007 Elsevier B.V. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000253875500008
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/16681
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
YU HUILEI,Xu JH,Lu WY,et al. Environmentally benign synthesis of natural glycosides using apple seed meal as green and robust biocatalyst[J]. J. Biotechnol.,2008,133(4):469-477.
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