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学科主题: 天然产物有机化学
题名: Concise asymmetric synthesis of (+)-CP-99,994 and (+)-L-733,060 via efficient construction of homochiral syn-1,2-diamines and syn-1,2-amino alcohols
其他题名: Concise asymmetric synthesis of (+)-CP-99,994 and (+)-L-733,060 via efficient construction of homochiral syn-1,2-diamines and syn-1,2-amino alcohols
作者: LIU RUNHUA ; Fang K(方凯) ; Wang B(王并) ; Xu MH(徐明华) ; Lin GQ(林国强)
通讯作者: 王并 ; 徐明华 ; 林国强
刊名: J. Org. Chem.
发表日期: 2008
卷: 73, 期:8, 页:3307-3310
收录类别: SCI
部门归属: 复旦大学; 上海有机所
英文摘要: An efficient asymmetric synthesis of human NK-1 SP receptor antagonists (+)-CP-99,994 and (+)-L-733,060 was achieved starting from a common chiral intermediate (5). Our route featured the SmI2-induced reductive coupling of N-tert-butanesulfinyl imine (7) with aldehyde (6) as the key step as well as pivotal transformations of the anti-1,2-amino alcohol thus obtained to homochiral syn-1,2-amino alcohol and syn-1,2-diamine for the asymmetric synthesis of 2,3-disubstituted piperidines.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000254883700048
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/16675
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
LIU RUNHUA,Fang K,Wang B,et al. Concise asymmetric synthesis of (+)-CP-99,994 and (+)-L-733,060 via efficient construction of homochiral syn-1,2-diamines and syn-1,2-amino alcohols[J]. J. Org. Chem.,2008,73(8):3307-3310.
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