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学科主题: 天然产物有机化学
题名: A new synthesis of 4, 4-diaryl/diheteroaryl-3-butenyl derivatives of nipecotic acids as GABA transporter inhibitors inhibitor
其他题名: GABA转运抑制剂的哌啶甲酸的4,4-二芳基/二杂芳基-3-丁烯基衍生物的合成
作者: Zhang JG(张建革) ; Jiang CS(蒋昌盛) ; Lin GQ(林国强) ; Wen R(闻韧)
通讯作者: 林国强 ; 闻韧
刊名: Chin. Chem. Lett.
发表日期: 2005-01-01
卷: 16, 期:9, 页:1205-1208
收录类别: SCI
部门归属: 复旦大学; 中科院上海有机化学研究所
英文摘要: A new method for the synthesis of 4, 4-diaryl/diheteroaryl-3-butenyl derivatives of nipecotic acid as GABA transporter inhibitors is described. The key intermediates 4-tosyl-1, 1-diaryl/diheteroaryl-1-butene 10a-d were synthesized by Wittig reaction, and followed by alkylation with (R)-3-piperidinecarboxylate. The resulting N-cycloalkylated amino acid esters 11a-d were saponified and then acidified to get the target compounds 1a-d. The preliminary bioassays showed that 1a-d exhibited excellent inhibition of [H-3]-GABA uptake in vitro of culture cells.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/16637
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Zhang JG,Jiang CS,Lin GQ,et al. A new synthesis of 4, 4-diaryl/diheteroaryl-3-butenyl derivatives of nipecotic acids as GABA transporter inhibitors inhibitor[J]. Chin. Chem. Lett.,2005,16(9):1205-1208.
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