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学科主题: 生命有机化学
题名: Synthesis of novel and enantiomerically pure epoxypropylamine: a divergent route to the chiral β-adrenergic blocking agents
其他题名: 新型环氧丙胺单一对映体的合成: 发散型合成光学纯的贤上腺素β-阻断剂
作者: Hou XL(侯雪龙) ; Li BF(李冰峰) ; Dai LX(戴立信)
通讯作者: 侯雪龙
刊名: Tetrahedron-Asymmetry
发表日期: 1999-01-01
卷: 10, 页:2319-2326
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所金属有机化学开放实验室
英文摘要: The chiral building block (S)-N-benzyl-N-isopropyl-2,3-epoxypropylamine is obtained by means of chlorohydroxylation of allylamine, followed by Jacobsen's hydrolytic kinetic resolution with water. A concise, divergent five-step synthesis of three β-adrenergic blocking agents in high enantiomeric excess using (S)-N_benzyl-N-isopropyl-2,3-epoxypropylamine as the key intermediate is described.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15813
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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Recommended Citation:
Hou XL,Li BF,Dai LX. Synthesis of novel and enantiomerically pure epoxypropylamine: a divergent route to the chiral β-adrenergic blocking agents[J]. Tetrahedron-Asymmetry,1999,10:2319-2326.
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