中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 金属有机化学国家重点实验室  > 期刊论文
学科主题: 有机化学
题名: 在多糖衍生物类色谱柱上手性拆分β-氨基醇及β-羟基硫醚类化合物
其他题名: Direct enantiomeric separation of β-Aminoalcohols and β-hydroxy sulfides using polysaccharide derivatives as chiral stationary phases
作者: 夏立钧 ; 吴诘 ; 唐民华 ; 侯雪龙 ; 戴立信
通讯作者: 夏立钧
刊名: 有机化学
发表日期: 1999-01-01
卷: 19, 期:6, 页:625-629
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所分析化学研究室(分析测试中心〕
摘要: 在以正己烷-异丙醇为移动相的体系中, 用Chiralce OD, Chiralcel OJ 及 Chiralpak AD 作为手性固定相对13种β-氨基醇及β-羟基硫醚类化合物对映体进行HPLC手性拆分,这些化合物至少能在一支柱上得到基线级分离。考察了它们于不同浓度配比的这类洗脱体系中在柱上的色谱行为。实验表明化合物取代基的性质明显影响它们在手性柱上的拆分。收性固定相与外消旋样品上的极性基团之间的氢键作用和π-π 作用可能是进行手性识别的主要原因。方法已用于非手性环氧化合物不对称开环反应产物β-氨基醇-β-羟基硫醚类化合物的光学纯度鉴定。
英文摘要: Direct enantiomeric separation of racemic mixtures of 13 β-amino alcohols and β-hydroxyb sulfides was achieved by HPLC using Chiralcel OD, Chiralcel OJ and Chiralpak AD as chiral stationary phases and hexane/2-propanol mixture as eluent. These reacemates were completely separated into enantiomers at least on one of these stationary phases. The chromatographic parameters of these racemates on AD,OD and OJ columns at various rations of hexane/2-propanol were examined. The results showed that the properties of substituents of the compounds obviously had effects on their resolution on columns. The hydrogen bonding and π-πinteractions between the chiral stationary phase and the polar group of racemates may be responsible for the chiral recognition. This method had been applied to determination of the optical purity of the product from asymmetric ring opeining of meso-epoxides.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15803
Appears in Collections:金属有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
990050.pdf(304KB)----开放获取--View Download

Recommended Citation:
夏立钧,吴诘,唐民华,等. 在多糖衍生物类色谱柱上手性拆分β-氨基醇及β-羟基硫醚类化合物[J]. 有机化学,1999,19(6):625-629.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[夏立钧]'s Articles
[吴诘]'s Articles
[唐民华]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[夏立钧]‘s Articles
[吴诘]‘s Articles
[唐民华]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 990050.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace