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学科主题: 生命有机化学
题名: Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
其他题名: Beclin 1 通过调节USP10和USP13的去泛素化活性来调控p53的蛋白水平
作者: Liu JL(刘军力) ; Xia HG(夏宏光) ; Kim, Minsu ; Xu LH(徐立华) ; Li Y(李盈) ; Zhang LH(张立红) ; Cai Y(蔡雨) ; Norberg, Helin Vakifahmetoglu ; Zhang T(张涛) ; Furuya, Tsuyoshi ; Jin MZ(金明志) ; Zhu, Zhimin ; Wang, Huanchen ; Yu, Jia ; Li YX(李彦霞) ; Hao, Yan ; Choi, Augustine ; Ke, Hengming ; Ma DW(马大为) ; Yuan JY(袁钧瑛)
通讯作者: 马大为 ; 袁钧瑛
刊名: Cell
发表日期: 2011
卷: 147, 期:1, 页:223-234
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 哈佛大学医学院
英文摘要: Autophagy is an important intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of autophagy named "spautin-1" for specific and potent autophagy inhibitor-1. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Beclin1 is a tumor suppressor and frequently monoallelically lost in human cancers. Interestingly, Beclin1 also controls the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities. Since USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Our study provides a molecular mechanism involving protein deubiquitination that connects two important tumor suppressors, p53 and Beclin1, and a potent small molecule inhibitor of autophagy as a possible lead compound for developing anticancer drugs.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000295396700028
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15675
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Liu JL,Xia HG,Kim, Minsu,et al. Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13[J]. Cell,2011,147(1):223-234.
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