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Synthetic Studies toward Communesins
其他题名对communesins的合成研究
Zuo ZW(左智伟); Ma DW(马大为)
2011
发表期刊Isr. J. Chem.
ISSN0021-2148
卷号51期号:3-4页码:434-441
摘要Communesins A-H are a growing family of natural products isolated from a marine fungal strain of Penicillium species. Preliminary biological evaluation has revealed that these compounds possess insecticidal activity and cytotoxicity against several tumor cell lines. Their interesting biological activities and unique structures have attracted considerable attention of synthetic chemists worldwide. To date, several elegant protocols for assembling the core structure of these indole alkaloids have been described, including intermolecular Diels-Alder reaction of methylated aurantioclavine with quinine methide imine and intramolecular hetero Diels-Alder reaction of the azaortho-xylylene intermediates. Recently, three completed total syntheses for communesin F have been disclosed, in which the crucial vicinal quaternary stereogenic centers were constructed by employing an intramolecular cyclopropanation; an intramolecular Heck reaction of a tetrasubstituted alkene, or an oxidative coupling of a 3-substituted indole, as the key step. Accompanying the total synthesis, the absolute configuration of natural communesin F was established as 6R, 7R, 8R, 9S, 11R. However, total syntheses of other members of communesin family that contain an epoxide moiety have not been achieved, which will stimulate more synthetic studies.
学科领域生命有机化学
部门归属中科院上海有机化学研究所
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收录类别SCI
语种英语
WOS记录号WOS:000290380100010
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/15671
专题生命有机化学国家重点实验室
通讯作者Ma DW(马大为)
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Zuo ZW,Ma DW. Synthetic Studies toward Communesins[J]. Isr. J. Chem.,2011,51(3-4):434-441.
APA 左智伟,&马大为.(2011).Synthetic Studies toward Communesins.Isr. J. Chem.,51(3-4),434-441.
MLA 左智伟,et al."Synthetic Studies toward Communesins".Isr. J. Chem. 51.3-4(2011):434-441.
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