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学科主题: 生命有机化学
题名: Synthetic Studies toward Communesins
其他题名: 对communesins的合成研究
作者: Zuo ZW(左智伟) ; Ma DW(马大为)
通讯作者: 马大为
刊名: Isr. J. Chem.
发表日期: 2011
卷: 51, 期:3-4, 页:434-441
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Communesins A-H are a growing family of natural products isolated from a marine fungal strain of Penicillium species. Preliminary biological evaluation has revealed that these compounds possess insecticidal activity and cytotoxicity against several tumor cell lines. Their interesting biological activities and unique structures have attracted considerable attention of synthetic chemists worldwide. To date, several elegant protocols for assembling the core structure of these indole alkaloids have been described, including intermolecular Diels-Alder reaction of methylated aurantioclavine with quinine methide imine and intramolecular hetero Diels-Alder reaction of the azaortho-xylylene intermediates. Recently, three completed total syntheses for communesin F have been disclosed, in which the crucial vicinal quaternary stereogenic centers were constructed by employing an intramolecular cyclopropanation; an intramolecular Heck reaction of a tetrasubstituted alkene, or an oxidative coupling of a 3-substituted indole, as the key step. Accompanying the total synthesis, the absolute configuration of natural communesin F was established as 6R, 7R, 8R, 9S, 11R. However, total syntheses of other members of communesin family that contain an epoxide moiety have not been achieved, which will stimulate more synthetic studies.
语种: 英语
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WOS记录号: WOS:000290380100010
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15671
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Zuo ZW,Ma DW. Synthetic Studies toward Communesins[J]. Isr. J. Chem.,2011,51(3-4):434-441.
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