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学科主题: 生命有机化学
题名: Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents
其他题名: 含1,3,3,4-四取代吡咯烷的CCR5受体拮抗剂的构效关系研究, 第一部分: N-取代基的调整
作者: Li B(李本) ; JONES ERIC DALE ; ZHOU ENKUN ; LI CHEN ; BAYLIS DEAN CAMERON ; Yu SH(余尚海) ; Wang M(汪淼) ; HE XING ; COATES JONATHAN ALAN VICTOR ; RHODES DAVID IAN ; Pei G(裴刚) ; DEADMAN JOHN JOSEPH ; Xie X(谢欣) ; Ma DW(马大为)
通讯作者: DEADMAN JOHN JOSEPH ; 谢欣 ; 马大为
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2010
卷: 20, 期:14, 页:4012-4014
收录类别: SCI
部门归属: 上海生化所; Avexa公司; 中国科学院上海药物研究所; 上海靶点公司; 中国科学院上海有机化学研究所
英文摘要: A novel series of CCR5 antagonists has been identified, utilizing the lead, nifeviroc, which were further modified based on bioisosteric principles. Lead optimization was pursued by balancing potential toxicity and potency. Potent analogues with low toxic properties were successfully developed by formation of urea and amide bonds at the nitrogen at position 4- of the pyrrolidine ring. (C) 2010 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000279258800002
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15645
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Li B,JONES ERIC DALE,ZHOU ENKUN,et al. Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents[J]. Bioorg. Med. Chem. Lett.,2010,20(14):4012-4014.
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