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Total synthesis of antimicrobial and antitumor cyclic depsipeptides
其他题名抗菌和抗肿瘤的环酯肽的全合成
Li WH(李文华); SCHLECKER ANDREAS; Ma DW(马大为)
2010
发表期刊Chem. Commun.
ISSN1359-7345
卷号46期号:30页码:5403-5420
摘要The total synthesis of natural products "has to be viewed as an art and a science that needs to be advanced for its own sake" (K. C. Nicolaou) and indeed, the achievements within this field of chemistry during the last decades are astonishing. However, besides its inherent beauty, total synthesis also opens the gates widely to a better understanding of biological processes and the development of pharmaceutical interesting substances. Cyclic depsipeptides form one of the compound classes that have attracted tremendous attention from synthetic chemists. They often feature non-proteinogenic amino acids and various types of structural unique building blocks, which make them challenging targets for synthetic efforts. Their total synthesis offers the chance to implement the use of newly developed synthetic tools in a complex environment. Synthetic dead-ends have shown the limitations of today's chemistry as well as triggering the development of new methodologies to circumvent the observed problems. Cyclic depsipeptides also often possess biological properties, especially antimicrobial and antitumor activity, that make them promising candidates for further pharmaceutical investigations and thus have a value at their own. Furthermore, through construction from scratch, ambiguities regarding the structure of several members of that compound class could be successfully clarified and derivatives for structure-activity-relationship (SAR) studies obtained.
学科领域生命有机化学
部门归属中国科学院上海有机化学研究所
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收录类别SCI
语种英语
WOS记录号WOS:000280145000001
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/15637
专题生命有机化学国家重点实验室
通讯作者Ma DW(马大为)
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GB/T 7714
Li WH,SCHLECKER ANDREAS,Ma DW. Total synthesis of antimicrobial and antitumor cyclic depsipeptides[J]. Chem. Commun.,2010,46(30):5403-5420.
APA 李文华,SCHLECKER ANDREAS,&马大为.(2010).Total synthesis of antimicrobial and antitumor cyclic depsipeptides.Chem. Commun.,46(30),5403-5420.
MLA 李文华,et al."Total synthesis of antimicrobial and antitumor cyclic depsipeptides".Chem. Commun. 46.30(2010):5403-5420.
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