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学科主题: 生命有机化学
题名: Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases
其他题名: Smac的有效非肽类似物的设计,合成及测定
作者: Sun W(孙威) ; Nikolovska-Coleska, Zaneta ; Qin DG(秦东光) ; Sun HY(孙海鹰) ; Yang, ChaoYie ; Bai,Longchuang ; Qiu, Su ; Wang Y(王优) ; Ma DW(马大为) ; Wang SM(王少萌)
通讯作者: 马大为 ; 王少萌
刊名: J. Med. Chem.
发表日期: 2009
卷: 52, 期:3, 页:593-596
收录类别: SCI
部门归属: 上海有机所; 密歇根大学
英文摘要: A series of new Smac mimetics have been designed, synthesized, and evaluated. The most potent compound 10 binds to XIAP, cIAP-1, and cIAP-2 BIR3 proteins with K-i of 3.9, 0.37, and 0.25 nM, respectively. Compound 10 antagonizes XIAP in a cell-free functional assay and induces rapid cIAP-1 degradation in cancer cells. Compound 10 inhibits cell growth in the MDA-MB-231 cancer cell line with an IC50 of 8.9 nM.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000263142400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15617
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Sun W,Nikolovska-Coleska, Zaneta,Qin DG,et al. Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases[J]. J. Med. Chem.,2009,52(3):593-596.
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