中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
其他题名: 环酯肽毒素通过分子伴侣介导的自吞噬作用促进Hsp90事件蛋白降解
作者: Shen, Shensi ; Zhang PT(张澎涛) ; Lovchik, Martin A. ; Li, Ying ; Tang, Liuya ; Chen, Zhimin ; Zeng, Rong ; Ma DW(马大为) ; Yuan JY(袁钧英) ; Yu Q(俞强)
通讯作者: 马大为 ; 袁钧英 ; 俞强
刊名: J. Cell Biol.
发表日期: 2009
卷: 185, 期:4, 页:629-639
收录类别: SCI
部门归属: 上海药物所; 上海有机所; 哈佛医学院
英文摘要: Promoting the degradation of Hsp90 client proteins by inhibiting Hsp90, an important protein chaperone, has been shown to be a promising new anticancer strategy. In this study, we show that an oxazoline analogue of apratoxin A (oz-apraA), a cyclodepsipeptide isolated from a marine cyanobacterium, promotes the degradation of Hsp90 clients through chaperone-mediated autophagy (CMA). We identify a KFERQ-like motif as a conserved pentapeptide sequence in the kinase domain of epidermal growth factor receptor (EGFR) necessary for recognition as a CMA substrate. Mutation of this motif prevents EGFR degradation by CMA and promotes the degradation of EGFR through the proteasomal pathway in oz-apraA-treated cells. Oz-apraA binds to Hsc70/Hsp70. We propose that apratoxin A inhibits Hsp90 function by stabilizing the interaction of Hsp90 client proteins with Hsc70/Hsp70 and thus prevents their interactions with Hsp90. Our study provides the first examples for the ability of CMA to mediate degradation of membrane receptors and cross talks of CMA and proteasomal degradation mechanisms.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000266279900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15611
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2009290.pdf(3034KB)----开放获取--View Download

Recommended Citation:
Shen, Shensi,Zhang PT,Lovchik, Martin A.,et al. Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy[J]. J. Cell Biol.,2009,185(4):629-639.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shen, Shensi]'s Articles
[张澎涛]'s Articles
[Lovchik, Martin A.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shen, Shensi]‘s Articles
[张澎涛]‘s Articles
[Lovchik, Martin A.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2009290.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace