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学科主题: 生命有机化学
题名: Metal-Catalyzed Derivatization of C-alpha-Tetrasubstituted Amino Acids and Their Use in the Synthesis of Cyclic Peptides
其他题名: 金属催化的C-alpha-四取代氨基酸的衍生化及在环肽合成中的应用
作者: Grauer, Andreas ; Spaeth, Andreas ; Ma DW(马大为) ; Koenig, Burkhard
通讯作者: Koenig, Burkhard
刊名: Chem.-Asian J.
发表日期: 2009-01-01
卷: 4, 期:7, 页:1134-1140
收录类别: SCI
部门归属: Univ Regensburg; 上海有机所
英文摘要: C-alpha-tetrasubstituted amino acids are important building blocks in the design and preparation of novel peptidomimetics. We report on the functionalization of the C-alpha-tetrasubstituted THF amino acid rac-5 by copper(I) catalyzed N-arylation reactions. The aryl bromide substituent of rac-5 is replaced by a variety of aliphatic and aromatic amines. Intramolecular N-arylation yielded only small amounts of a cyclic tripeptide 2, whereas cyclic tripeptide ethers 4 and 50 were obtained in an enantiomerically pure form from a palladium(0)-catalyzed intramolecular O-arylation.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000267893100016
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15601
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Grauer, Andreas,Spaeth, Andreas,Ma DW,et al. Metal-Catalyzed Derivatization of C-alpha-Tetrasubstituted Amino Acids and Their Use in the Synthesis of Cyclic Peptides[J]. Chem.-Asian J.,2009,4(7):1134-1140.
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