中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities synthesis
其他题名: 环酯肽Apratoxin A及其类似物的全合成及生物活性评价
作者: Ma DW(马大为) ; Zou B(邹斌) ; Cai GR(蔡国荣) ; Xiaoyi Hu ; Jun O. Liu
通讯作者: 马大为
刊名: Chem.-Eur. J.
发表日期: 2006-01-01
卷: 12, 期:29, 页:7615-7626
收录类别: SCI
部门归属: Rutgers State Univ, Dept Chem, Piscataway, NJ 08854 USA.; 中科院上海有机化学研究所
英文摘要: A novel total synthesis of apratoxin A is described, with key steps including the assembly of its ketide segment through a D-proline-catalyzed direct aldol reaction and Oppolzer's anti aldol reaction and the preparation of its thiazoline unit in a biomimetic synthesis. An oxazoline analogue of apratoxin A has also been elaborated by a similar approach. This compound has a potency against HeLa cell proliferation only slightly lower than that of apratoxin A, whilst a C(40)-demethylated oxazoline analogue of apratoxin A displays a much lower cytotoxicity and the C(37)epimer and C(37)-demethylation product of this new analogue are inactive. These results suggest that the two methyl groups at C(37) and C(40) and the stereochemistry at C(37) are essential for the potent cellular activity of the oxazoline analogue of apratoxin A. Further biological analysis revealed that both synthetic apratoxin A and its oxazoline analogue inhibited cell proliferation by causing cell cycle arrest in the G1 phase.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15509
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2006004.pdf(247KB)----开放获取--View Download

Recommended Citation:
Ma DW,Zou B,Cai GR,et al. Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities synthesis[J]. Chem.-Eur. J.,2006,12(29):7615-7626.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[马大为]'s Articles
[邹斌]'s Articles
[蔡国荣]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[马大为]‘s Articles
[邹斌]‘s Articles
[蔡国荣]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2006004.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace