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A selective inhibitor-of eIF2 alpha dephosphorylation protects cells from ER stress
Alternative TitleA selective inhibitor-of eIF2 alpha dephosphorylation protects cells from ER stress
Michael Boyce1; Kevin F. Bryant; Céline Jousse; Long K(龙凯); Heather P.Harding; Donalyn Scheuner; Ma DW(马大为); Donald M. Coen; David Ron; Yuan JY(袁钧瑛)
2005
Source PublicationScience
ISSN0036-8075
Volume307Issue:5711Pages:935-939
AbstractMost protein phosphatases have little intrinsic substrate specificity, making selective pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a screen for small molecules that protect cells from endoplasmic reticulum (ER) stress, we,identified salubrinal, a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha). Salubrinal also blocks eIF2alpha dephosphorylation mediated by a herpes simplex virus protein and inhibits viral replication. These results suggest that selective chemical inhibitors of eIF2a dephosphorylation may be useful in diseases involving ER stress or viral infection. More broadly, salubrinal demonstrates the feasibility of selective pharmacological targeting of cellular dephosphorylation events.
Subject Area生命有机化学
Department上海有机所; Harvard Univ
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000226985100057
Citation statistics
Cited Times:947[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/15499
Collection生命有机化学国家重点实验室
Corresponding AuthorKevin F. Bryant; Céline Jousse; Long K(龙凯)
Recommended Citation
GB/T 7714
Michael Boyce1,Kevin F. Bryant,Céline Jousse,et al. A selective inhibitor-of eIF2 alpha dephosphorylation protects cells from ER stress[J]. Science,2005,307(5711):935-939.
APA Michael Boyce1.,Kevin F. Bryant.,Céline Jousse.,龙凯.,Heather P.Harding.,...&袁钧瑛.(2005).A selective inhibitor-of eIF2 alpha dephosphorylation protects cells from ER stress.Science,307(5711),935-939.
MLA Michael Boyce1,et al."A selective inhibitor-of eIF2 alpha dephosphorylation protects cells from ER stress".Science 307.5711(2005):935-939.
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